Key result
Selenium and ACA reduce doxorubicin-induced kidney damage and lower serum urea and creatine.
Why the study?
Doxorubicin is an essential antitumor drug, but its clinical use is limited by serious adverse effects across multiple organs.
Does Selenium and N-(p-Amylcinnamoyl) anthranilic acid reduce doxorubicin-induced kidney injury in rats?
Does Selenium and N-(p-Amylcinnamoyl) anthranilic acid reduce doxorubicin-induced kidney injury in rats?
p-value: p=<0.05
Selenium and ACA may serve as therapeutic agents to suppress renal dysfunction and oxidative DNA damage following doxorubicin-induced kidney injury in a rat model.
May mitigate doxorubicin nephrotoxicity in rats; hypothesis-generating and leaves open clinical translation.
Doxorubicin (DOXR) is one of the essential antitumor drugs. However, its serious adverse effects in many organs limit the clinical use of DOXR. This study aimed to investigate the effect of selenium (Se) and N-(p-Amilcinnamoyl) anthranilic acid (ACA) on kidney tissue in DOXR-administered rats. The rats in the study were divided into six groups (n=10); Control, DMSO, DOXR, DOXR+Se, DOXR+ACA and DOXR+Se+ACA. At the end of the study, intracardiac blood was drawn from rats, and kidney tissues were removed. Urea and creatine levels were measured in serum samples of rats. In addition, histopathological examination of kidney tissue was determined by H&E staining, and 8-OHdG expression was determined by immunohistochemical analysis. Urea and creatine levels increased with DOXR decreased in serum samples after Se and ACA treatments (p< 0.05). While glomerular atrophy, tubular and glomerular dilatation, vascular occlusion and degeneration of tubular epithelial cells were observed in the DOXR group, significant improvement was observed in the Se and ACA treatment groups. In addition, Se and ACA treatments reduced DOXR-induced 8-OHdG expression (p< 0.05). These findings indicated that Se and ACA could be used as critical therapeutic agents to suppress renal dysfunction and oxidative DNA damage that can occur after DOXR-induced kidney injury.
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Yıldızhan et al. (2022) studied Doxorubicin-induced kidney injury (n=60). Selenium and N-(p-amylcinnamoyl) anthranilic acid (ACA) vs. Doxorubicin alone was evaluated on Serum urea and creatine levels, and 8-OHdG expression (p=<0.05). Selenium and ACA treatments significantly reduced doxorubicin-induced increases in serum urea and creatine levels, improved histopathological kidney damage, and decreased 8-OHdG expression (p<0.05).
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