Key result
Selenium administration prevented structural damage to liver tissues and ameliorated doxorubicin-induced hepatotoxicity in female rats.
Why the study?
Clinical use of doxorubicin is limited by liver toxicity, but data regarding the protective effect of selenium on doxorubicin-induced liver damage are lacking.
Does selenium prevent doxorubicin-induced hepatotoxicity in a rat model?
Does selenium prevent doxorubicin-induced hepatotoxicity in a rat model?
Selenium demonstrates a protective effect against doxorubicin-induced hepatotoxicity in rats by modulating pro-inflammatory cytokines.
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Does not support clinical selenium use with doxorubicin; leaves open translation to human cardio-oncology.
Özge et al. (2020) studied Doxorubicin-induced hepatotoxicity. Selenium vs. Doxorubicin alone / Control was evaluated on Liver histopathology, TNF-α, IL-1β expression levels, and PCNA activity. Selenium administration prevented structural damage to liver tissues and ameliorated doxorubicin-induced hepatotoxicity in female rats.
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