Key result
Patients with CPVT frequently exhibit sinus node dysfunction and inducible atrial tachyarrhythmias, indicating that the disease's arrhythmogenic substrate involves supraventricular tissues.
Observational (n=8)
Patients with CPVT frequently exhibit sinus node dysfunction and inducible atrial tachyarrhythmias, suggesting the disease pathogenesis involves broader regions of the heart beyond the ventricular myocardium.
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SN dysfunction and inducible flutter may coexist in CPVT; leaves open whether EP testing refines risk stratification.
BACKGROUND: This study was performed to investigate the frequency and importance of supraventricular arrhythmia and sinus node (SN) dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT). METHODS AND RESULTS: Eight patients with CPVT (mean age: 16.8+/-8.1 years) underwent an electrophysiological study. SN recovery time (1,389+/-394 ms) was slightly prolonged, and 4 of 8 patients had abnormal values. Atrial flutter (AF) was induced by low-rate atrial pacing in 2 patients and by isoproterenol infusion in 1 patient. Atrial fibrillation (Af) was induced by isoproterenol infusion in 2 patients. One patient presented with Af during the follow-up period, and 2 of 4 patients with AF/Af presented with increased SN recovery time. CONCLUSIONS: Patients with CPVT frequently have associated with SN dysfunction, and inducible atrial tachyarrhythmias, which indicate that the pathogenesis of CPVT is limited not only to the ventricular myocardium, but also to broad regions of the heart, including the SN and atrial muscle.
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Sumitomo et al. (2007) conducted an observational in Catecholaminergic polymorphic ventricular tachycardia (CPVT) (n=8). Catecholaminergic polymorphic ventricular tachycardia (CPVT) was evaluated on Frequency of sinus node dysfunction and inducible atrial tachyarrhythmias. Patients with CPVT frequently exhibit sinus node dysfunction and inducible atrial tachyarrhythmias, indicating that the disease's arrhythmogenic substrate involves supraventricular tissues.
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