Key result
Children on haemodialysis had significantly higher pre-dialysis aortic augmentation index (29.7% vs 8.3%) and pulse wave velocity (6.6 vs 5.4 m/s) compared with matched controls (P<0.0001).
Why the study?
Does end-stage renal disease requiring haemodialysis increase arterial stiffness in children compared to healthy controls?
Population
14 children on haemodialysis and 15 age and height matched healthy children controls
Comparison
End-stage renal disease requiring haemodialysis vs Age and height matched healthy children controls
Design
Case-control
Authors
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Elevated arterial stiffness in children on hemodialysis may warrant monitoring; leaves open its prognostic value and response to interventions.
Case-Control (n=29)
Does end-stage renal disease requiring haemodialysis increase arterial stiffness in children compared to healthy controls?
Absolute Event Rate: 29.7% vs 8.3%
p-value: p=<0.0001
Children on haemodialysis exhibit significantly increased arterial stiffness compared to healthy controls, which is not ameliorated by a single dialysis session, suggesting structural rather than functional alterations.
Covic et al. (2005) conducted a case-control in End-stage renal disease on haemodialysis (n=29). Haemodialysis (End-stage renal disease) vs. Age and height matched children controls was evaluated on Pre-HD aortic augmentation index (AIx) (p=<0.0001). Children on haemodialysis had significantly higher pre-dialysis aortic augmentation index (29.7% vs 8.3%) and pulse wave velocity (6.6 vs 5.4 m/s) compared with matched controls (P<0.0001).
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