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This research aims to assess the prognostic significance of BAL lymphocytes and neutrophils in interstitial lung diseases.

December 13, 2024CellsOpen Access

Predictive Value of Flow Cytometry Quantification of BAL Lymphocytes and Neutrophils in ILD

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This research aims to assess the prognostic significance of BAL lymphocytes and neutrophils in interstitial lung diseases.
Retrospective analysis of 1074 patients with ILD using bronchoalveolar lavage samples.
Flow cytometry was used for quantification of lymphocytes and neutrophils in BAL.
Risk stratification groups were established based on BAL cell counts.
Patients with favorable risk had an overall survival of 10.0 ± 1.4 years, while intermediate and unfavorable groups had 5.8 ± 0.6 and 3.0 ± 0.3 years, respectively (p < 0.001).
The risk scoring model showed an independent predictive factor for overall survival (HR = 1.859, p = 0.002).
Fibrosis status was also a significant predictor (HR = 2.081, p < 0.001).

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Randomized retrospective analysis correlates BAL cell counts with clinical outcomes in ILD, suggesting a predictive risk scoring model.

Novoa-Bolivar et al. (2024) studied this question.

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