Key result
Severe psychiatric disorders are associated with an increased risk of cardiometabolic diseases, potentially driven by shared pathophysiological mechanisms such as inflammation and insulin resistance.
Why the study?
Individuals with severe psychiatric disorders face increased risk of underdiagnosed and undertreated general medical conditions, particularly cardiovascular and metabolic diseases, but the basis for this comorbidity remains poorly understood.
Inflammation and related factors like dysbiosis and insulin resistance may underlie the increased risk of cardiometabolic diseases in patients with severe psychiatric disorders, offering potential therapeutic targets.
Answers are grounded in this paper and cite their sources.
Highlights inflammation's role in psychiatric-cardiometabolic comorbidity; leaves open whether targeting dysbiosis or insulin resistance improves outcomes.
Individuals with severe psychiatric disorders, such as mood disorders and schizophrenia, are at increased risk of developing other medical conditions, especially cardiovascular and metabolic diseases. These medical conditions are underdiagnosed and undertreated in these patients contributing to their increased morbidity and mortality. The basis for this increased comorbidity is not well understood, possibly reflecting shared risks factors (e.g. lifestyle risk factors), shared biological mechanisms and/or reciprocal interactions. Among overlapping pathophysiological mechanisms, inflammation and related factors, such as dysbiosis and insulin resistance, stand out. Besides underlying the association between psychiatric disorders and cardiometabolic diseases, these mechanisms provide several potential therapeutic targets.
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Teixeira et al. (2022) conducted a review in Severe psychiatric disorders and cardiometabolic comorbidities. Severe psychiatric disorders was evaluated. Severe psychiatric disorders are associated with an increased risk of cardiometabolic diseases, potentially driven by shared pathophysiological mechanisms such as inflammation and insulin resistance.
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