The natural history of latent rheumatic heart disease in a 5 year follow-up study: a prospective observational study
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Key result
Over a 5-year follow-up, latent rheumatic heart disease in school pupils showed a variable natural history, with 52.3% of cases regressing, 31.8% persisting, and 15.9% progressing.
Population
55 school pupils identified with latent rheumatic heart disease, of which 44 were available for follow-up.
Design
Cohort
Follow-up
median 60.8 months (IQR 51.3-63.5)
Authors
Discussion
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Implication
Suggests dynamic WHF trajectories; hypothesis-generating and should not yet change practice.
Study Design
Type
Observational (n=44)
Multicenter
No
Structured PICO
P
Population
44 school pupils with latent rheumatic heart disease (mean age 13.8 years, 65.9% female) were followed for a median of 60.8 months to assess disease progression.
O
Outcome
Progression, persistence or regression of latent RHD assessed by World Heart Federation (WHF) echocardiographic criteriasurrogate
Latent rheumatic heart disease has a variable natural history over 5 years, with nearly half of cases regressing to normal, while others persist or progress.
Limitations
- Small sample size
- Did not perform auscultation at the time of enrolment
- Cannot make inferences regarding the time interval from the initial attack of ARF to entry
- 20% loss to follow-up rate
Cite This Study
Zühlke et al. (2016) conducted an observational in Latent rheumatic heart disease (n=44). Latent rheumatic heart disease was evaluated on Progression, persistence, or regression of latent RHD by WHF category. Over a 5-year follow-up, latent rheumatic heart disease in school pupils showed a variable natural history, with 52.3% of cases regressing, 31.8% persisting, and 15.9% progressing.
Topics
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