Key result
CRP/Alb, NLR, and PLR ratios were significantly correlated with APACHE II scores (p<0.001), and higher NLR and CRP/Alb ratios were associated with mortality in acute exacerbation of CKD.
Why the study?
The study aimed to evaluate the relationship between CRP/Alb, NLR, and PLR ratios with the APACHE II score and 28-day mortality in ICU patients.
Observational (n=400)
p-value: p=<0.001
Inflammatory markers such as the CRP/albumin ratio and neutrophil/lymphocyte ratio correlate with APACHE II scores and are associated with mortality in ICU patients with acute exacerbation of CKD.
May aid risk stratification in acute CKD exacerbation; hypothesis-generating for inflammatory ratios beyond APACHE II, needs prospective validation.
Objectives This study aimed to evaluate the relationship between C-reactive protein/albumin (CRP/Alb), neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR) ratios and the Acute Physiology And Chronic Health Evaluation II (APACHE II) score and 28-day mortality among 400 patients admitted to internal medicine and anesthesia reanimation intensive care unit (ICU). Methods This prospective study included a total of 400 patients who were admitted to hospital internal medicine and anesthesia reanimation ICUs. Results The most common reasons for ICU admission were pneumonia (29.3%), gastrointestinal bleeding (10.3%), acute exacerbation of chronic kidney disease (CKD) (10.3%), and acute kidney injury (7.5%). The comparison of the laboratory findings with survival outcomes revealed that among the patients with acute exacerbation of CKD, the median NLR (p=0.043) and median CRP/Alb (p=0.021) were significantly higher in patients who died. For all of the patients, the APACHE II score was positively correlated with CRP (p<0.001) and CRP/Alb (p<0.001), negatively correlated with Alb (p<0.001), positively correlated with the NLR (p<0.001), and positively correlated with the PLR. Conclusions The APACHE II score was significantly correlated with the CRP/Alb ratio, NLR, and PLR. The NLR and CRP/Alb ratio were statistically associated with mortality in patients hospitalized for acute exacerbation of CKD.
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Usta et al. (2021) conducted an observational in Intensive care unit admission (n=400). CRP/Alb, NLR, and PLR ratios was evaluated on Correlation with APACHE II score and 28-day mortality (p=<0.001). CRP/Alb, NLR, and PLR ratios were significantly correlated with APACHE II scores (p<0.001), and higher NLR and CRP/Alb ratios were associated with mortality in acute exacerbation of CKD.
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