Review summarizes translational biomarker discovery for sepsis, highlighting clinical implications and interdisciplinary approaches.
Sepsis remains a major global health burden characterized by high mortality and diagnostic uncertainty. Advances in laboratory medicine have made it a central field in translational biomarker discovery, integrating molecular biology, bioinformatics, and clinical sciences. This review summarizes recent evidence with a focus on the translational trajectory from biomarker identification to clinical implementation, including protein biomarkers, cellular biomarkers, and RNA profiling. Emphasis is placed on patient phenotyping approaches, multi-marker strategies, integrating multidimensional parameters from different biological systems by modern classifiers, and the evolving role of laboratory medicine as an interdisciplinary nucleus for improving sepsis diagnosis and prognostication.
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Friedrich et al. (2026) studied this question.
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