Comparison of the c-reactive protein-mean arterial pressure ratio with critical care prognostic scoring systems

Aim: We hypothesized that the C-reactive protein (CRP)-mean arterial pressure (MAP) ratio could predict short-term mortality in critically ill patients. In this study, our aim was to compare the CRP-MAP ratio with the acute physiology and chronic health evaluation (APACHE II) score in predicting the short-term mortality of critically ill patients. Material and Methods: This research was designed as a prospective observational study and included critically ill patients aged over 18 years, who were admitted to the intensive care unit from the emergency department between December 10, 2021, and March 10, 2022. The patients' demographic and clinical data and 28-day mortality status were recorded. Results: We included 169 patients in this study. The median age was 72 (25th-75th percentiles: 61-81) years, and 74 (43%) of the patients were female. The CRP-MAP ratio was significantly higher in the non-survivor group than in the survivor group [1.03 (0.194-2.24) and 0.207 (0.0346-1.1), respectively, p<0.001]. The APACHE II score was also significantly higher in the non-survivor group than in the survivor group [26 (20.8-30) and 21 (15-25.8), respectively, p < 0.001]. The odds ratio of the CRP-MAP value was similar to those of the APACHE II score and blood urea nitrogen-albumin ratio (3.819, 2.545, and 3.67, respectively). Discussion: There was a significant difference in mortality between the patients with CRP-MAP ratios below and above the cut-off value of 4.2. According to the results of our study, the CRP-MAP ratio was as significant as APACHE II in the prediction of mortality.