Key result
Cross-bridge compliance is relatively low (0.37 ± 0.12 nm pN−1) and fully accounted for by the elasticity of the myosin head, indicating isometric force is generated by a small sub-step.
Population
Sartorius muscles of Rana esculenta and single muscle fibres in rigor
Design
Preclinical
Authors
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No immediate clinical implications; extends molecular models of isometric force generation.
Cross-bridge compliance in muscle sarcomeres is relatively low and fully accounted for by the elasticity of the myosin head, suggesting isometric force is generated by a small sub-step of the 11 nm stroke.
Brunello et al. (2014) studied Skeletal muscle mechanics. Mechanical and X-ray diffraction experiments was evaluated on Combined filament compliance and cross-bridge compliance. Cross-bridge compliance is relatively low (0.37 ± 0.12 nm pN−1) and fully accounted for by the elasticity of the myosin head, indicating isometric force is generated by a small sub-step.
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