Sars-Cov-2 Re-Infection: The Analysis of Cases of Mechanisms

This article examines the problem of re-infection with COVID-19 infection, provides a general description of the situation caused by coronavirus reinfection as of December 2020, conducts an in-depth analysis of all published data with similar cases, and analyzes the molecular mechanisms of secondary infection. In December 2019, a series of cases of pneumonia of unknown origin was registered in the Chinese city of Wuhan, and later local outbreaks of simi- lar symptoms of diseases. A month later, scientists were able to identify the causative agent of the disease: it turned out to be a new coronavirus (2019-nCoV), which causes diseases in humans. There is evidence that the Sars-CoV-2 strain VUI 202012/01, identified at the end of 2020, is characterized by a significantly greater ability to spread among humans (an increase in transmissivity of up to 70%), and an increase in the reproductive number (R) of 0.4 or more is also expected. Currently, there are no officially confirmed cases of re-infection with this variant of SARS-CoV-2. How- ever, it is suggested that patients who have previously had COVID-19 caused by any of the existing strains of the new coronavirus may be more susceptible to re-infection with the VUI 202012/01 strain. This can due to some mutations contribution to the escape of the VUI 202012/01 virus from the immune response.