Key result
The mutant T allele of the AGT gene was detected at a two-fold increased frequency in patients with basal cell carcinoma compared to healthy controls (p <0.001).
Why the study?
Basal cell carcinoma has been genetically associated with increased ACE expression, but the association with genetic variability in other renin-angiotensin system factors including AGT, AGTR1, and AGTR2 was unknown.
Are polymorphisms in the AGT, AGTR1, and AGTR2 genes associated with the risk of basal cell carcinoma?
Case-Control (n=190)
Are polymorphisms in the AGT, AGTR1, and AGTR2 genes associated with the risk of basal cell carcinoma?
Increased expression of the AGT gene (mutant T allele) may be associated with an increased risk of basal cell carcinoma.
AGT M235T variant associated with BCC risk; leaves open whether RAS polymorphisms influence skin cancer susceptibility.
BACKGROUND/AIM: Basal cell carcinoma (BCC) has been genetically associated with an increased expression of angiotensin-converting enzyme (ACE), an important factor of the renin-angiotensin system which produces vasoconstrictor angiotensin II. Other factors of this system include angiotensinogen (AGT) and angiotensin receptors AGTR1, AGTR2. We investigated the possible association of BCC with genetic variability in the AGT, AGTR1 and AGTR2 genes. MATERIALS AND METHODS: DNA samples of 190 Greeks were studied, including 91 patients with BCC and 99 matched healthy controls. Molecular genotyping of patients and controls was performed for the polymorphisms AGT M235T, AGTR1 A1166C and AGTR2 G1675A. RESULTS: The mutant T allele that increases AGT gene expression was detected in two-fold increased frequency in BCC patients in comparison to healthy controls (p <0.001). On the contrary, no significant difference was observed in AGTR1 and AGTR2 variants between patients and controls. CONCLUSION: Increased expression of AGT may be associated with BCC.
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PAPAGGELOPOULOS et al. (2019) conducted a case-control in Basal cell carcinoma (n=190). AGT M235T, AGTR1 A1166C and AGTR2 G1675A polymorphisms vs. Matched healthy controls was evaluated on Frequency of the mutant T allele of the AGT gene (p=<0.001). The mutant T allele of the AGT gene was detected at a two-fold increased frequency in patients with basal cell carcinoma compared to healthy controls (p <0.001).
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