Key result
Adriamycin exposure in isolated adult rat cardiomyocytes induced both apoptosis and necrosis, which were significantly reduced by the antioxidant trolox.
Why the study?
Does trolox inhibit adriamycin-induced apoptosis and necrosis in isolated adult rat cardiomyocytes?
Population
Isolated adult rat cardiomyocytes
Comparison
Exposure to 20 microM adriamycin for 1 h, with… vs Unexposed cardiomyocytes or adriamycin alone
Design
Preclinical
Follow-up
0-23 h post-treatment
Authors
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Trolox may protect against doxorubicin cardiotoxicity; leaves open translation from rat cardiomyocytes to clinical practice.
Does trolox inhibit adriamycin-induced apoptosis and necrosis in isolated adult rat cardiomyocytes?
Adriamycin-induced cell death in cardiomyocytes involves both apoptosis and necrosis mediated by oxidative stress, which can be attenuated by the antioxidant trolox.
Kumar et al. (1999) studied Adriamycin-induced cardiomyopathy. Adriamycin and Trolox vs. Unexposed / Adriamycin without Trolox was evaluated on Apoptosis and necrosis (cell shape changes, DNA fragmentation). Adriamycin exposure in isolated adult rat cardiomyocytes induced both apoptosis and necrosis, which were significantly reduced by the antioxidant trolox.
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