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June 17, 2010Journal of Cardiovascular Electrophysiology

Programming Antitachycardia Pacing for Primary Prevention in Patients With Implantable Cardioverter Defibrillators: Results From the PROVE Trial

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Key result

In patients receiving ICDs or CRT-Ds for primary prevention, programming for antitachycardia pacing successfully terminated 92% of ventricular tachycardia episodes.

Why the study?

Does antitachycardia pacing (ATP) improve successful termination of ventricular tachycardia in patients with ICDs or CRT-Ds for primary prevention?

Population

830 patients with implantable cardioverter defibrillators or cardiac resynchronization therapy…

Design

Cohort

Follow-up

12 months

Authors

MSMohammad SaeedElectrophysiologyCNCURTIS NEASONSt. Jude Medical CenterMRMehdi RazaviAmerican Heart Association

Discussion

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Implication

ATP programming in primary prevention ICDs was associated with high VT termination rates; leaves open whether it reduces shocks or improves outcomes.

Study Design

Type

Observational (n=830)

Multicenter

Yes

Structured PICO

Does antitachycardia pacing (ATP) improve successful termination of ventricular tachycardia in patients with ICDs or CRT-Ds for primary prevention?

P
Population
830 patients (mean age 67.3 years, 27% female) receiving ICDs or CRT-Ds for primary prevention, followed for up to 12 months.
E
Exposure
Antitachycardia pacing (ATP) programmed for ventricular tachycardia (VT) cycle lengths of 270-330 ms.
O
Outcome
Incidence of ventricular tachycardia (VT) and the rate of successful termination by antitachycardia pacing (ATP)surrogate

Programming antitachycardia pacing in primary prevention ICD/CRT-D patients successfully terminates the vast majority of ventricular tachycardia episodes, potentially reducing the need for painful shocks.

Cite This Study

Saeed et al. (2010) conducted an observational in Primary prevention of sudden cardiac death (n=830). Antitachycardia pacing (ATP) programming was evaluated on Successful termination of ventricular tachycardia (VT) by ATP. In patients receiving ICDs or CRT-Ds for primary prevention, programming for antitachycardia pacing successfully terminated 92% of ventricular tachycardia episodes.

synapsesocial.com/papers/6a628b660582df600cc3c346https://doi.org/10.1111/j.1540-8167.2010.01825.x

Topics

Cardiac device therapyVentricular arrhythmias
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supraventricular Tachycardia‐Ventricular Tachycardia Discrimination Algorithms in Implantable Cardioverter Defibrillators: State‐of‐the‐Art Review2001 · 127 citations
  2. 2Improved Survival with an Implanted Defibrillator in Patients with Coronary Disease at High Risk for Ventricular Arrhythmia1996 · 4,187 citations
  3. 3Comparison of Fixed Burst Versus Decremental Burst Pacing for Termination of Ventricular Tachycardia1993 · 42 citations
  4. 4Differences in Tachyarrhythmia Detection and Implantable Cardioverter Defibrillator Therapy by Primary or Secondary Prevention Indication in Cardiac Resynchronization Therapy Patients2004 · 835 citations
  5. 5Shock Reduction Using Antitachycardia Pacing for Spontaneous Rapid Ventricular Tachycardia in Patients With Coronary Artery Disease2001 · 333 citations