Key result
Hypertension was associated with severe intimal thickening, with endothelin-A receptor mRNA localized just beneath the luminal endothelium in intimal smooth muscle cells.
Population
12 patients undergoing cardiovascular surgery providing internal mammary artery specimens
Authors
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Endothelin-A receptor expression in hypertensive intima warrants clinical caution; leaves open its role in intimal proliferation.
Observational (n=12)
Endothelin-A receptor gene expression is differentially regulated between the intima and media, which may influence intimal smooth muscle cell proliferation in hypertension.
Hasegawa et al. (1994) conducted an observational in Hypertension (n=12). Hypertension vs. Patients without hypertension was evaluated on Expression of endothelin-A receptor gene in the thickened arterial intima. Hypertension was associated with severe intimal thickening, with endothelin-A receptor mRNA localized just beneath the luminal endothelium in intimal smooth muscle cells.
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