Key result
Methylmethacrylate at concentrations of 0.312% or higher significantly depressed zymosan-induced chemotactic activity and polymorphonuclear leukocyte migration in vitro.
Why the study?
Does methylmethacrylate affect the chemotaxis of polymorphonuclear leukocytes in vitro?
Population
Human polymorphonuclear leukocytes (in vitro)
Comparison
Methylmethacrylate (concentrations up to 1.25%) vs Control (no methylmethacrylate)
Design
Preclinical
Authors
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May impair host defense around bone cement; hypothesis-generating from in vitro data, needs in vivo confirmation.
Does methylmethacrylate affect the chemotaxis of polymorphonuclear leukocytes in vitro?
Methylmethacrylate inhibits polymorphonuclear leukocyte chemotaxis and migration in vitro at concentrations of 0.312% and above.
William Petty (1978) studied this question. Methylmethacrylate was evaluated on Chemotaxis of polymorphonuclear leukocytes. Methylmethacrylate at concentrations of 0.312% or higher significantly depressed zymosan-induced chemotactic activity and polymorphonuclear leukocyte migration in vitro.