Key result
Isolated sleep hypertension was associated with thicker carotid intima-media thickness (0.69 vs 0.64 mm, P=0.017) and faster brachial-ankle pulse wave velocity (1299 vs 1183 cm/s, P<0.001).
Why the study?
High sleep blood pressure is an independent cardiovascular risk factor, prompting investigation into whether timer-equipped home device measurements associate with large artery stiffness.
Is home device-measured sleep hypertension associated with increased large artery stiffness in a general population?
Cross-Sectional (n=5,916)
Is home device-measured sleep hypertension associated with increased large artery stiffness in a general population?
Effect estimate: IMT: β = 0.051; baPWV: β = 0.141
p-value: p=<0.001
Home device-measured sleep blood pressure is independently associated with large artery stiffness, suggesting it may help identify cardiovascular risks missed by office or morning measurements.
Home sleep BP associates with arterial stiffness; hypothesis-generating and leaves open incremental prognostic value.
BACKGROUND: High sleep blood pressure (BP) has been suggested to be an independent risk factor for cardiovascular outcomes. To assess the applicability of sleep BP measured using a timer-equipped home device, we investigated the association between home device-measured sleep BP and large artery stiffness. METHODS: We performed a cross-sectional analysis of a dataset from the Nagahama study (N = 5916), a general population-based cohort study. Home morning BP and sleep BP were measured using a timer-equipped cuff-oscillometric device (HEM-7080IC). Office BP, carotid intima--media thickness (IMT), and brachial--ankle pulse wave velocity (baPWV) were measured at the follow-up investigation of the Nagahama study. RESULTS: Sleep hypertension (SBP ≥120 mmHg and/or DBP ≥70 mmHg) was associated with the arterial parameters (IMT: β = 0.051, baPWV: β = 0.141, both P < 0.001) independently of morning hypertension (IMT: β = 0.093, baPWV: β = 0.216, both P < 0.001) irrespective of antihypertensive medication status. Individuals exhibiting isolated sleep hypertension (N = 801) had thicker IMT (0.69 ± 0.14 vs. 0.64 ± 0.13 mm, P = 0.017) and faster baPWV (1,299 ± 197 vs. 1,183 ± 178 cm/s, P < 0.001) than normotensives. A sleep SBP at least 110 mmHg and a sleep DBP at least 65 mmHg were identified as the lower threshold BP values for the association with arterial parameters. CONCLUSION: Sleep BP measurement using a home device may be a simple way to assess cardiovascular risks overlooked by office and home morning BP measurements.
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Tabara et al. (2020) conducted a cross-sectional in General population (n=5,916). Sleep hypertension vs. Normotensives was evaluated on Carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) (IMT: β = 0.051; baPWV: β = 0.141, p=<0.001). Isolated sleep hypertension was associated with thicker carotid intima-media thickness (0.69 vs 0.64 mm, P=0.017) and faster brachial-ankle pulse wave velocity (1299 vs 1183 cm/s, P<0.001).
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