Higher blood pressure increased the risk of all-cause mortality, with a more pronounced effect in younger men aged 40 to 49 years (HR per 10-mm Hg SBP increase 1.37; 95% CI 1.15-1.62).
Meta-Analysis (n=176,389)
Yes
Does high blood pressure increase the risk of all-cause mortality in Japanese participants without prior cardiovascular disease?
High blood pressure significantly increases the risk of all-cause mortality in the Japanese population, with the relative impact being more pronounced in younger individuals.
Hazard Ratio: 1.37 (95% CI 1.15–1.62)
Hypertension is a leading cause of death because of cardiovascular disease and predominantly affects total mortality. To reduce avoidable deaths from hypertension, we need to collect blood pressure data and assess their impact on total mortality. To examine this issue, a meta-analysis of 13 cohort studies was conducted in Japan. Poisson regression was used for estimating all-cause mortality rates and ratios. In the model, blood pressure data were treated as continuous (10-mm Hg increase) and categorical (every 10 mm Hg) according to recommendations of the Seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of Hypertension. Potential confounders included body mass index, smoking, drinking, and cohort. The impact of hypertension was measured by the population-attributable fraction. After excluding participants with cardiovascular disease history, 176 389 participants were examined in the analysis. Adjusted mortality rates became larger as the blood pressure increased, and these were more distinct in younger men and women. Hazard ratios also showed the same trends, and these trends were more apparent in younger men (hazard ratio unit: 10-mm Hg increase aged 40 to 49 years: systolic blood pressure 1.37 (range: 1.15 to 1.62); diastolic blood pressure 1.46 range: 1.05 to 2.03) than older ones (hazard ratio: aged 80 to 89 years: systolic blood pressure 1.09 range: 1.05 to 1.13and diastolic blood pressure 1.12 range: 1.03 to 1.22). Population-attributable fraction of hypertension was approximately 20% when the normal category was used as a reference level and was 10% when we included the prehypertension group in the reference level. In conclusion, high blood pressure raised the risk of total mortality, and this trend was higher in the younger Japanese population.
Murakami et al. (Tue,) conducted a meta-analysis in Hypertension (n=176,389). Blood pressure increase (per 10-mm Hg) vs. Normal blood pressure category was evaluated on All-cause mortality (HR 1.37, 95% CI 1.15-1.62). Higher blood pressure increased the risk of all-cause mortality, with a more pronounced effect in younger men aged 40 to 49 years (HR per 10-mm Hg SBP increase 1.37; 95% CI 1.15-1.62).