Key result
Elevated systolic blood pressure (≥160 mmHg) significantly increased the risk of coronary events in hypercholesterolemic men (RR 6.79) and women (RR 9.31) compared to those with systolic blood pressure <130 mmHg.
Why the study?
Do elevated blood pressure and cholesterol levels increase the risk of coronary events and stroke in Japanese hypercholesterolemic patients treated with simvastatin?
Cohort (n=47,294)
Open-label
Yes
Do elevated blood pressure and cholesterol levels increase the risk of coronary events and stroke in Japanese hypercholesterolemic patients treated with simvastatin?
Relative Risk: 6.79 (95% CI 3.38–13.68)
p-value: p=<0.001
In Japanese hypercholesterolemic patients on low-dose simvastatin, elevated blood pressure and poor lipid control synergistically increase the risk of stroke and coronary events, highlighting the need for strict dual control.
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BP control may reduce CV events in statin-treated hypercholesterolemic patients; leaves open optimal targets for trials.
Shimamoto et al. (2005) conducted a cohort in Hypercholesterolemia (n=47,294). Elevated systolic blood pressure (≥160 mmHg) vs. Systolic blood pressure <130 mmHg was evaluated on Coronary events in males (RR 6.79, 95% CI 3.38-13.68, p=<0.001). Elevated systolic blood pressure (≥160 mmHg) significantly increased the risk of coronary events in hypercholesterolemic men (RR 6.79) and women (RR 9.31) compared to those with systolic blood pressure <130 mmHg.
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