Key result
For every 10 ms decrease in the standard deviation of normal-to-normal intervals, the risk of sudden cardiac death or resuscitated cardiac arrest increased significantly (HR 1.153) in patients with stable coronary artery disease.
Why the study?
Because CAD mortality has declined with advancing medical and interventional or surgical treatments, the prognostic value of heart rate variability in CAD in the current treatment era is not well established.
Does baseline heart rate variability predict specific modes of mortality in patients with stable coronary artery disease?
Population
1,757 ARTEMIS study patients with angiographically verified CAD
Comparison
Baseline heart rate variability measures
Design
Observational cohort study
Follow-up
Average 8.7 ± 2.2 years
Authors
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Baseline HRV may refine long-term risk estimates in CAD on modern therapy; leaves open incremental value for decision-making.
Observational (n=1,757)
No
Does baseline heart rate variability predict specific modes of mortality in patients with stable coronary artery disease?
Hazard Ratio: 1.153 (95% CI 1.075–1.236)
p-value: p=<0.001
Impairment of heart rate variability predicts overall mortality but is not associated with any specific mode of death in patients with stable CAD, limiting its clinical applicability for targeted therapy.
Vuoti et al. (2021) conducted an observational in Coronary artery disease (n=1,757). 10 ms decrease in standard deviation of normal-to-normal intervals (SDNN) vs. Higher SDNN was evaluated on Sudden cardiac death or resuscitated cardiac arrest (SCD/SCA) (HR 1.153, 95% CI 1.075-1.236, p=<0.001). For every 10 ms decrease in the standard deviation of normal-to-normal intervals, the risk of sudden cardiac death or resuscitated cardiac arrest increased significantly (HR 1.153) in patients with stable coronary artery disease.
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