What question did this study set out to answer?

This research aims to explore the relationship between heart rate variability measured via electrocardiograms and cardiac mortality among the elderly.

December 15, 1999American Journal of EpidemiologyOpen Access

Both Decreased and Increased Heart Rate Variability on the Standard 10-Second Electrocardiogram Predict Cardiac Mortality in the Elderly: The Rotterdam Study

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: General elderly population (n=5272). Intervention: Decreased and increased heart rate variability (SDNN) vs. Third quartile of SDNN. Primary outcome: Cardiac mortality (HR 1.8, 95% CI 1.0-3.2).

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Key result

Both decreased (lowest quartile, HR 1.8; 95% CI 1.0-3.2) and increased (highest quartile, HR 2.3; 95% CI 1.3-4.0) heart rate variability predicted cardiac mortality in older adults.

Why the study?

Does heart rate variability on a 10-second ECG predict cardiac mortality in elderly individuals?

Key Points

This research aims to explore the relationship between heart rate variability measured via electrocardiograms and cardiac mortality among the elderly.
Analyzed heart rate variability (SDNN) using a standard 10-second electrocardiogram in a cohort of 5,272 older adults (≥55 years) from the Rotterdam Study.
Excluded individuals with arrhythmia and fewer than six normal R-R intervals, focusing on the association with mortality outcomes.
Used Cox's proportional hazards model to assess the risk for cardiac and all-cause mortality across quartiles of SDNN.
Lowest quartile of SDNN associated with an 80% increased risk for cardiac mortality (HR = 1.8; 95% CI: 1.0, 3.2) compared to the third quartile.
Highest quartile of SDNN showed a 130% increased risk for cardiac mortality (HR = 2.3; 95% CI: 1.3, 4.0).
Adjustments for potential confounders did not significantly alter risk estimates.

Study Design

Type

Cohort (n=5,272)

Structured PICO

Does heart rate variability on a 10-second ECG predict cardiac mortality in elderly individuals?

Population

5,272 men and women aged ≥55 years without arrhythmia, followed for a mean of 4 years.

Exposure

Heart rate variability (SDNN) measured on a standard 10-second electrocardiogram (lowest and highest quartiles)

Comparator

Third quartile of SDNN

Outcome

Cardiac mortalityhard clinical

Main Result

Hazard Ratio: 1.8 (95% CI 1–3.2)

Both decreased and increased heart rate variability on a standard 10-second ECG are associated with an increased risk of cardiac mortality in the elderly.

Discussion

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Implication

May inform ECG-based mortality risk assessment in older adults; leaves open prospective validation before clinical adoption.

Cite This Study

Bruyne et al. (1999) conducted a cohort in General elderly population (n=5,272). Decreased and increased heart rate variability (SDNN) vs. Third quartile of SDNN was evaluated on Cardiac mortality (HR 1.8, 95% CI 1.0-3.2). Both decreased (lowest quartile, HR 1.8; 95% CI 1.0-3.2) and increased (highest quartile, HR 2.3; 95% CI 1.3-4.0) heart rate variability predicted cardiac mortality in older adults.

synapsesocial.com/papers/6a6d31bf2163a0a01bc2c39e https://doi.org/10.1093/oxfordjournals.aje.a009959

Topics

Women and heart disease

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Both Decreased and Increased Heart Rate Variability on the Standard 10-Second Electrocardiogram Predict Cardiac Mortality in the Elderly: The Rotterdam Study

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Topics

Both Decreased and Increased Heart Rate Variability on the Standard 10-Second Electrocardiogram Predict Cardiac Mortality in the Elderly: The Rotterdam Study

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider