Key result
High intensity inspiratory muscle training improved functional status and exercise capacity in chronic heart failure patients, and significantly altered soluble TNF receptor I compared to low intensity training (P<0.01).
Why the study?
Does high intensity inspiratory muscle training improve exercise capacity and inflammatory markers in patients with chronic heart failure?
Population
38 patients with chronic heart failure, age 57+/-2 years, New York Heart Association classification II-III.
Comparison
High intensity inspiratory muscle training. vs Low intensity inspiratory muscle training.
Design
Cohort
Follow-up
10 weeks
Authors
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Inspiratory muscle training effects on cytokines in HF remain unknown; leaves open any clinical role pending larger trials.
RCT (n=38)
Does high intensity inspiratory muscle training improve exercise capacity and inflammatory markers in patients with chronic heart failure?
p-value: p=<0.01
High intensity inspiratory muscle training improves functional status and exercise capacity in chronic heart failure patients, but does not significantly alter systemic inflammatory markers.
Laoutaris et al. (2007) conducted an RCT in chronic heart failure (n=38). High intensity inspiratory muscle training vs. Low intensity inspiratory muscle training (15% of sustained maximal inspiratory pressure) was evaluated on soluble TNF receptor I change (p=<0.01). High intensity inspiratory muscle training improved functional status and exercise capacity in chronic heart failure patients, and significantly altered soluble TNF receptor I compared to low intensity training (P<0.01).
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