Key result
Labile hypertension was associated with elevated cardiac output, mild fixed hypertension with increased peripheral resistance, and severe fixed hypertension with high blood volume and cardiac output.
Why the study?
Do hemodynamic patterns (cardiac output, peripheral resistance, blood volume) differ across stages of essential hypertension compared to normotensive controls?
Cross-Sectional (n=57)
Do hemodynamic patterns (cardiac output, peripheral resistance, blood volume) differ across stages of essential hypertension compared to normotensive controls?
Essential hypertension exhibits distinct hemodynamic profiles across its stages, evolving from elevated cardiac output in labile phases to increased peripheral resistance in fixed phases.
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Elevated cardiac output in labile hypertension may inform subclassification; leaves open progression mechanisms to fixed disease.
Finkielman et al. (1965) conducted a cross-sectional in Essential Hypertension (n=57). Essential hypertension vs. Normotensive control subjects was evaluated on Hemodynamic patterns including cardiac output, arterial blood pressure, run-off index, flow cessation pressure, and blood volume. Labile hypertension was associated with elevated cardiac output, mild fixed hypertension with increased peripheral resistance, and severe fixed hypertension with high blood volume and cardiac output.
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