Key result
Autonomic neuropathy was present in 77% of patients with alcoholic liver disease compared to 14% with non-alcoholic liver disease, indicating alcohol abuse exaggerates vagal nerve dysfunction.
Why the study?
Does alcohol abuse exaggerate autonomic dysfunction in patients with chronic liver disease compared to non-alcoholic liver disease and healthy controls?
Population
27 patients with chronic liver disease and 56 healthy controls
Comparison
Chronic alcoholic liver disease vs Non-alcoholic liver disease and healthy controls
Design
Case-control
Authors
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Alcohol abuse may exacerbate autonomic neuropathy in liver disease; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=83)
Does alcohol abuse exaggerate autonomic dysfunction in patients with chronic liver disease compared to non-alcoholic liver disease and healthy controls?
Absolute Event Rate: 77% vs 14%
Autonomic, mainly vagal, nerve dysfunction is common in chronic liver disease and is significantly exacerbated by alcohol abuse.
Lindgren et al. (1996) conducted a cross-sectional in Chronic liver disease (n=83). Alcohol abuse (alcoholic liver disease) vs. Non-alcoholic liver disease and healthy controls was evaluated on Autonomic neuropathy. Autonomic neuropathy was present in 77% of patients with alcoholic liver disease compared to 14% with non-alcoholic liver disease, indicating alcohol abuse exaggerates vagal nerve dysfunction.
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