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August 1, 1989QJM

Autonomic Neuropathy and Chronic Liver Disease

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Why the study?

Is autonomic neuropathy present in non-alcoholic liver disease at a similar frequency to alcoholic liver disease?

Population

64 patients with biopsy-proven liver disease and 29 age-matched controls

Design

Cross-sectional

Authors

PTPaul J. ThuluvathGoethe University FrankfurtDTD. R. TrigerLong Island University

Discussion

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Implication

Highlights autonomic neuropathy across liver diseases; hypothesis-generating for mechanisms beyond alcohol toxicity.

Structured PICO

Is autonomic neuropathy present in non-alcoholic liver disease at a similar frequency to alcoholic liver disease?

P
Population
64 patients with biopsy-proven liver disease (22 with alcoholic liver disease and 42 with non-alcoholic liver disease) and 29 age-matched controls
C
Comparator
29 age-matched controls
O
Outcome
Autonomic function (parasympathetic and sympathetic damage)surrogate

Autonomic neuropathy occurs with comparable frequency in both alcoholic and non-alcoholic liver disease, suggesting it may be secondary to disturbed liver function rather than alcohol toxicity alone.

Cite This Study

Thuluvath et al. (1989) studied this question.

synapsesocial.com/papers/6a8a75421fb56efa37d4a034https://doi.org/10.1093/oxfordjournals.qjmed.a068366
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Autonomic neuropathy in patients with hepatic cirrhosis2003 · 55 citations
  2. 2Autonomic neuropathy in an alcoholic population1987 · 63 citations
  3. 3Alcohol Abuse Exaggerates Autonomic Dysfunction in Chronic Liver Disease1996 · 16 citations
  4. 4Neuropathy as an Extrahepatic Manifestation of Chronic Liver Diseases1998 · 17 citations
  5. 5Autonomic Dysfunction in Patients of Alcoholic Liver Cirrhosis2020