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February 12, 2008European Neurology

Autonomic Neuropathy in Chronic Alcoholism: Evaluation of Cardiovascular, Pupillary and Sympathetic Skin Responses

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Why the study?

Does chronic alcoholism impair autonomic nerve function compared to healthy subjects?

Population

30 chronic alcoholics and 30 healthy subjects

Comparison

Chronic alcoholism (observational exposure) vs Healthy subjects

Design

Case-control

Authors

RMRamón MirallesUniversitat Autònoma de BarcelonaJEJosep M. EspadalerHospital Del MarXNXavier NavarroUniversitat Autònoma de Barcelona

Discussion

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Implication

May support autonomic testing in symptomatic alcoholics; leaves open whether interventions alter outcomes in prospective studies.

Structured PICO

Does chronic alcoholism impair autonomic nerve function compared to healthy subjects?

P
Population
30 chronic alcoholics and 30 healthy subjects
I
Intervention
Chronic alcoholism (observational exposure)
C
Comparator
Healthy subjects
O
Outcome
Autonomic nerve function assessed by cardiovascular function tests, pupil cycle time (PCT), and sympathetic skin responses (SSR)surrogate

Chronic alcoholism is associated with significant sympathetic and parasympathetic autonomic neuropathy, which correlates with nutritional status.

Cite This Study

Miralles et al. (2008) studied this question.

synapsesocial.com/papers/6a8a75369be9d02581bdb1cahttps://doi.org/10.1159/000117151
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Autonomic neuropathy in an alcoholic population1987 · 63 citations
  2. 2THE SYMPATHETIC NERVOUS SYSTEM IN ALCOHOLIC NEUROPATHY1975 · 85 citations
  3. 3VAGAL NEUROPATHY IN CHRONIC ALCOHOLICS: RELATION TO ETHANOL CONSUMPTION1989 · 44 citations
  4. 4Erectile dysfunction as a sentinel symptom of cardiovascular autonomic neuropathy in heavy drinkers2004 · 27 citations
  5. 5Sympathetic vasoconstrictor nerve function in alcoholic neuropathy1984 · 12 citations