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June 1, 1984Clinical Physiology

Sympathetic vasoconstrictor nerve function in alcoholic neuropathy

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Why the study?

Does chronic alcoholism with polyneuropathy impair sympathetic vasoconstrictor nerve function?

Population

18 male chronic alcoholics admitted for intellectual impairment or polyneuropathy

Comparison

Assessment of sympathetic veno-arteriolar… vs Internal comparison between patients with…

Design

Cross-sectional

Authors

KJKai JensenUniversity of CopenhagenAKAndersen KvAleris Hamlet HospitalOHOle HenriksenRoche (Switzerland)

Discussion

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Implication

May suggest sympathetic vasomotor impairment in severe alcoholic polyneuropathy; hypothesis-generating, needs prospective confirmation before clinical adoption.

Structured PICO

Does chronic alcoholism with polyneuropathy impair sympathetic vasoconstrictor nerve function?

P
Population
18 male chronic alcoholics admitted for intellectual impairment or polyneuropathy
I
Intervention
Assessment of sympathetic veno-arteriolar axon-reflex using local 133Xenon washout technique (lowering ankle 40 cm below heart level in supine position) and 45 degrees passive head-up tilt
C
Comparator
Internal comparison between patients with moderate to severe polyneuropathy and patients with no or only mild polyneuropathy
O
Outcome
Decrease in tissue blood flow upon lowering the ankle 40 cm below heart level (sympathetic veno-arteriolar axon-reflex)surrogate

Chronic alcoholism can lead to dysfunction of peripheral sympathetic adrenergic nerve fibers, affecting vasomotor and pseudomotor nerves in addition to sensory and motor fibers.

Cite This Study

Jensen et al. (1984) studied this question.

synapsesocial.com/papers/6a7e7e22b2811efa75cd9ab7https://doi.org/10.1111/j.1475-097x.1984.tb00119.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE SYMPATHETIC NERVOUS SYSTEM IN ALCOHOLIC NEUROPATHY1975 · 85 citations
  2. 2Decreased Sympathetic Vasomotor Tone in Diabetic Orthostatic Hypotension1979 · 41 citations
  3. 3Normal sensory conduction in the nerves of the leg in man1971 · 182 citations
  4. 4Abnormality of a Thiamine-Requiring Enzyme in Patients with Wernicke-Korsakoff Syndrome1977 · 396 citations
  5. 5A Scale for Measuring the Severity of Alcoholism and Evaluating Its Treatment1979 · 14 citations