Key result
Long-term diabetic patients with signs of peripheral neuropathy showed significant parasympathetic impairments on deep breathing and orthostatic tests compared to healthy controls.
Why the study?
Are there detectable autonomic nervous function impairments in asymptomatic diabetic patients compared to healthy controls?
Population
52 long-term diabetic patients without symptoms of autonomic neuropathy and 31 age-matched healthy controls
Comparison
Autonomic function testing vs Age-matched healthy controls
Design
Case-control
Authors
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Supports autonomic testing in long-term diabetic neuropathy; hypothesis-generating for parasympathetic precedence over peripheral signs.
Case-Control (n=83)
Are there detectable autonomic nervous function impairments in asymptomatic diabetic patients compared to healthy controls?
In diabetic patients, parasympathetic autonomic neuropathy can be detected prior to the onset of peripheral neuropathy, whereas sympathetic denervation appears only in those with peripheral neuropathy.
Sundkvist Göran (1981) conducted a case-control in Diabetes (n=83). Long-term diabetes vs. Age-matched healthy controls was evaluated on Autonomic nervous function (parasympathetic and sympathetic impairments). Long-term diabetic patients with signs of peripheral neuropathy showed significant parasympathetic impairments on deep breathing and orthostatic tests compared to healthy controls.
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