What question did this study set out to answer?

To evaluate the prevalence of subclinical cardiac autonomic neuropathy and investigate its relationship with distal somatic neuropathy in diabetic patients without clinical autonomic symptoms.

July 16, 2009Experimental and Clinical Endocrinology & Diabetes

Impairment of Cardiorespiratory Reflexes and its Association with Distal Somatic Neuropathy in Diabetic Patients free from Clinical Symptoms of Autonomic Neuropathy

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Key result

No clinical data is available in the provided text, which consists only of the journal's editorial board information.

Why the study?

Is asymptomatic cardiac autonomic neuropathy associated with distal somatic neuropathy in diabetic patients?

Population

64 diabetic patients free from clinical symptoms of autonomic neuropathy, and 50 control subjects.

Design

Cross-sectional

Authors

GJGyörgy JermendyBajcsy-Zsilinszky Kórház és Rendelőintézet LTL TóthUniversity of Pecs PVPéter VörösHungarian Central Statistical Office

Discussion

Member takes

Implication

Absence of clinical data precludes practice changes; leaves open interpretation of this endocrinology research.

Key Points

To evaluate the prevalence of subclinical cardiac autonomic neuropathy and investigate its relationship with distal somatic neuropathy in diabetic patients without clinical autonomic symptoms.
Assessed 64 diabetic patients (36 type 1, 28 type 2) without clinical autonomic symptoms alongside 50 control subjects.
Evaluated cardiorespiratory reflexes using bedside tests, including deep-breathing, the Valsalva manoeuvre, and lying-to-standing postural shifts.
Quantified distal somatic neuropathy by measuring motor nerve conduction velocity in peroneal nerves.
Definitive cardiac autonomic neuropathy occurred in 28 patients (44%), early cardiac autonomic neuropathy in 19 patients (30%), and no alterations in 17 patients (26%).
Peroneal motor nerve conduction velocity was significantly lower in patients with definitive cardiac autonomic neuropathy (41.8 ± 0.7 m/s) compared to those without autonomic signs (45.8 ± 1.1 m/s, p < 0.01), both of which were significantly lower than controls (53.7 ± 0.7 m/s, p < 0.001).
Early or definitive cardiac autonomic neuropathy was present in 31 of 35 diabetic patients diagnosed with distal somatic neuropathy.

Structured PICO

Is asymptomatic cardiac autonomic neuropathy associated with distal somatic neuropathy in diabetic patients?

Population

64 diabetic patients (36 type 1, 28 type 2) free from clinical symptoms of autonomic neuropathy, and 50 control subjects.

Comparator

Control subjects and diabetic patients without signs of cardiac autonomic neuropathy

Outcome

Presence of cardiac autonomic neuropathy (assessed via deep-breathing, Valsalva manoeuvre, and lying-to-standing tests) and motor nerve conduction velocity in peroneal nervessurrogate

Abnormal cardiorespiratory reflexes indicating parasympathetic impairment are common in asymptomatic diabetic patients and are frequently associated with distal symmetrical somatic neuropathy.

Cite This Study

Jermendy et al. (2009) studied this question. No clinical data is available in the provided text, which consists only of the journal's editorial board information.

synapsesocial.com/papers/6a6e3bb65d37378ac1dbdc38 https://doi.org/10.1055/s-0029-1211010

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Impairment of Cardiorespiratory Reflexes and its Association with Distal Somatic Neuropathy in Diabetic Patients free from Clinical Symptoms of Autonomic Neuropathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Impairment of Cardiorespiratory Reflexes and its Association with Distal Somatic Neuropathy in Diabetic Patients free from Clinical Symptoms of Autonomic Neuropathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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