Key result
A high-fat diet with salt supplementation in rats for 20 weeks reduced functional capillary density in skeletal muscle (P<0.05) and induced cardiac remodeling and microcirculation rarefaction.
Why the study?
Does a high-fat diet with salt supplementation induce microvascular alterations and cardiac remodeling in Wistar Kyoto rats?
Does a high-fat diet with salt supplementation induce microvascular alterations and cardiac remodeling in Wistar Kyoto rats?
p-value: p=<0.05
A high-fat diet with salt supplementation for 20 weeks in rats successfully induces a metabolic syndrome model characterized by cardiac remodeling and microvascular rarefaction in the heart and skeletal muscle.
No takes yet. Share an insight, caveat, or question.
No basis for clinical translation in metabolic syndrome; leaves open microvascular contributions to diet-induced hypertension in humans.
Nascimento et al. (2013) studied Metabolic syndrome. High-fat diet (HFD) associated with salt supplementation vs. Standard chow was evaluated on Functional capillary density (FCD) (p=<0.05). A high-fat diet with salt supplementation in rats for 20 weeks reduced functional capillary density in skeletal muscle (P<0.05) and induced cardiac remodeling and microcirculation rarefaction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: