Key result
O-demethyl encainide potently blocked activated cardiac sodium channels at cold temperatures with no diastolic recovery, while at warmer temperatures diastolic recovery became detectable (tau ~25 s).
Why the study?
Does O-demethyl encainide block sodium channels in a temperature- and voltage-dependent manner in isolated guinea pig ventricular myocytes?
Does O-demethyl encainide block sodium channels in a temperature- and voltage-dependent manner in isolated guinea pig ventricular myocytes?
The electrophysiologic effects of O-demethyl encainide on cardiac sodium channels are highly temperature-dependent, cautioning against extrapolating cold-temperature in vitro data to clinical situations.
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Temperature-dependent ODE block cautions against extrapolating cold in vitro data to patients; leaves open physiologic relevance in humans.
Johns et al. (1989) studied this question. O-demethyl encainide (ODE) was evaluated on Sodium channel block and unblock characteristics. O-demethyl encainide potently blocked activated cardiac sodium channels at cold temperatures with no diastolic recovery, while at warmer temperatures diastolic recovery became detectable (tau ~25 s).
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