Key result
The 2019 HFMD and herpangina outbreak in Zunyi was predominantly caused by CVA6, CVA2, and CVA5, which were associated with significantly higher rates of severe infection (15.6% to 24.0%) compared to CVA16 (6.0%).
Why the study?
Hand, foot and mouth disease and herpangina are associated with enterovirus infections, but their molecular epidemiology and clinical features in Zunyi, China, during 2019 were not characterized.
Observational (n=1,377)
No
Absolute Event Rate: 19.1% vs 6%
p-value: p=<0.05
The 2019 HFMD/HA outbreak in Zunyi, China was predominantly driven by CVA6, CVA2, and CVA5, which were associated with more severe clinical features than CVA16.
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May inform regional HFMD/HA surveillance; leaves open broader applicability pending larger studies.
Ai et al. (2021) conducted an observational in Hand, foot, and mouth disease (HFMD) and herpangina (HA) (n=1,377). CVA6, CVA2, and CVA5 enterovirus infection vs. CVA16 enterovirus infection was evaluated on Severe HFMD/HA cases (p=<0.05). The 2019 HFMD and herpangina outbreak in Zunyi was predominantly caused by CVA6, CVA2, and CVA5, which were associated with significantly higher rates of severe infection (15.6% to 24.0%) compared to CVA16 (6.0%).
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