Key result
The VDR rs11574129 polymorphism (GA vs GG) was significantly associated with reduced susceptibility to CA16-associated hand, foot, and mouth disease (OR 0.068; 95% CI 0.007-0.693; P=.023).
Why the study?
Coxsackievirus A16 remains the most common causative agent of hand, foot, and mouth disease, and vitamin D receptor activity might affect infection outcomes.
Do VDR gene polymorphisms affect susceptibility to and severity of HFMD caused by coxsackievirus A16?
Case-Control
Do VDR gene polymorphisms affect susceptibility to and severity of HFMD caused by coxsackievirus A16?
Odds Ratio: 0.068 (95% CI 0.007–0.693)
p-value: p=.023
The VDR rs11574129 polymorphism may influence genetic susceptibility to CA16-associated hand, foot, and mouth disease.
VDR rs11574129 was associated with CA16 HFMD susceptibility; leaves open whether genotyping refines pediatric risk stratification.
Coxsackievirus A16 (CA16) remains the most common causative agent of hand, foot, and mouth disease (HFMD), and is related to high incidence and critical complications. Vitamin D receptor (VDR) activity might affect the outcome of CA16 infection. Our case-control research aims to evaluate the relationship between VDR polymorphisms in the gene encoding and susceptibility to and severity of HFMD due to CA16. Three single-nucleotide polymorphisms (SNPs) of VDR gene were selected according to functional prediction and linkage disequilibrium, and were examined utilizing the SNPscan method to identify possible associations with HFMD caused by CA16. A significant relationship was found in the HFMD cases of polymorphism rs11574129 (GA vs GG: odds ratio (OR) = 0.068, 95% confidence interval (CI) = 0.007-0.693, P = .023; GA + AA vs GG: OR = 0.322, 95%CI = 0.106-0.984, P = .047), and vitamin D levels in genotype AA were significantly higher than those in genotype GG (P < .05). These results suggest that VDR rs11574129 may influence genetic susceptibility to CA16-associated HFMD.
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Li et al. (2019) conducted a case-control in Hand, foot, and mouth disease (HFMD) caused by coxsackievirus A16. VDR gene polymorphism rs11574129 (GA genotype) vs. GG genotype was evaluated on Susceptibility to HFMD caused by CA16 (OR 0.068, 95% CI 0.007-0.693, p=.023). The VDR rs11574129 polymorphism (GA vs GG) was significantly associated with reduced susceptibility to CA16-associated hand, foot, and mouth disease (OR 0.068; 95% CI 0.007-0.693; P=.023).
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