Key result
Coxsackievirus A16 strains from children with severe hand, foot, and mouth disease were predominantly subgenotypes B1a and B1b, with a mean nucleotide substitution rate of 4.545 × 10^-3 per year.
Observational (n=13)
Subgenotype B1b of CV-A16 has become the predominant strain causing severe hand, foot, and mouth disease in Yunnan, China, with a specific nucleotide substitution rate that may inform vaccine development.
Monitoring B1b strains may guide regional surveillance; leaves open virulence and vaccine implications.
Coxsackievirus A16 (CV‐A16) commonly causes mild symptoms, but severe diseases, such as aseptic meningitis, encephalitis, and even fatal cases, have been reported. Thirteen CV‐A16 strains were isolated from patients with severe hand, foot, and mouth disease in Yunnan, Southwest China, from 2009 to 2015. Subgenotype B1a and B1b of CV‐A16 were predominantly circulating the region with B1b the predominant strain in recent years. The mean rate of nucleotide substitution based on the VP1 gene sequence was 4.545 × 10 −3 substitution per site per year from 2009 to 2015. These results may help in understanding the genetic diversity of CV‐A16 and develop a CV‐A16 vaccine.
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Zhang et al. (2018) conducted an observational in Severe hand, foot, and mouth disease (n=13). Coxsackievirus A16 strains was evaluated on Nucleotide substitution rate based on the VP1 gene sequence. Coxsackievirus A16 strains from children with severe hand, foot, and mouth disease were predominantly subgenotypes B1a and B1b, with a mean nucleotide substitution rate of 4.545 × 10^-3 per year.
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