Key result
Skeletal muscle dysfunction plays a pathophysiological role in exercise intolerance in patients with heart failure with preserved ejection fraction.
Why the study?
Skeletal muscle dysfunction contributes to exercise intolerance in HFpEF, and this review aimed to summarize the current understanding of skeletal muscle dysfunction in HFpEF.
This review highlights the pathophysiological role of skeletal muscle dysfunction in HFpEF and the need for precise mechanistic insights to develop targeted therapies.
Skeletal muscle dysfunction merits investigation as a contributor to HFpEF exercise intolerance; leaves open targeted therapies pending clinical trials.
PURPOSE OF REVIEW: Skeletal muscle dysfunction contributes to exercise intolerance, which manifests as dyspnea and fatiguability in patients with heart failure with preserved ejection fraction (HFpEF). This review aims to summarize the current understanding of skeletal muscle dysfunction in HFpEF. RECENT FINDINGS: Animal and human studies in HFpEF provide insights into the pathophysiological alterations in skeletal muscle structure and function with the identification of several molecular mechanisms. Exercise training and novel pharmacological therapies that target skeletal muscle are proposed as therapeutic interventions to treat HFpEF. SUMMARY: There is evidence that skeletal muscle dysfunction plays a pathophysiological role in HFpEF. However, precise mechanistic insights are needed to understand the contribution of skeletal muscle dysfunction in HFpEF.
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Saw et al. (2020) conducted a review in Heart failure with preserved ejection fraction (HFpEF). Skeletal muscle dysfunction was evaluated. Skeletal muscle dysfunction plays a pathophysiological role in exercise intolerance in patients with heart failure with preserved ejection fraction.
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