Key result
Chronic oral administration of sesame oil significantly prevented doxorubicin-induced alteration in biochemical parameters (p < 0.0001) and reduced myocardial TNF-α expression in rats.
Why the study?
Does sesame oil prevent doxorubicin-induced cardiotoxicity in a rat model?
Population
Male Wistar albino rats (180-200 g) subjected to an acute doxorubicin-induced cardiotoxicity model
Comparison
Sesame oil 5 or 10 ml/kg body weight orally for… vs Doxorubicin alone and probucol
Design
Preclinical
Follow-up
30 days of pretreatment
Authors
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Hypothesis-generating in rats; prospective human trials needed before clinical consideration.
Does sesame oil prevent doxorubicin-induced cardiotoxicity in a rat model?
p-value: p=< 0.0001
Pretreatment with sesame oil significantly attenuates doxorubicin-induced cardiotoxicity in rats by reducing oxidative stress and TNF-α expression.
Saleem et al. (2014) studied Doxorubicin-induced cardiotoxicity. Sesame oil vs. Doxorubicin alone was evaluated on Alteration in biochemical parameters (oxidative stress markers) and TNF-α expression (p=< 0.0001). Chronic oral administration of sesame oil significantly prevented doxorubicin-induced alteration in biochemical parameters (p < 0.0001) and reduced myocardial TNF-α expression in rats.
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