July 31, 2010European Journal of Heart Failure108 citationsOpen Access
View Full PaperRelations of Serum Phosphorus Levels to Echocardiographic Left Ventricular Mass and Incidence of Heart Failure in the Community
Key Result
Each 1 mg/dL increment in serum phosphorus was associated with a 1.74-fold increased risk of incident heart failure (95% CI 1.17-2.59) over a mean follow-up of 17.4 years.
Study Design
Type
Cohort (n=3,300)
Structured PICO
Does higher serum phosphorus increase the risk of incident heart failure and adverse left ventricular remodeling in a community-based population free of baseline cardiovascular and kidney disease?
P
Population
3,300 community-dwelling adults (mean age 44 years, 51% women) free of heart failure, myocardial infarction, and chronic kidney disease, followed for a mean of 17.4 years.
E
Exposure
Higher serum phosphorus levels (evaluated continuously per mg/dL increment and by highest quartile)
C
Comparator
Lower serum phosphorus levels (lowest quartile)
O
Outcome
Incident heart failure (prospective) and echocardiographic left ventricular measurements including LV mass, internal dimensions, and systolic dysfunction (cross-sectional)hard clinical
Higher serum phosphorus levels are independently associated with adverse left ventricular remodeling and a significantly increased risk of incident heart failure in a healthy community cohort.
Main Result
Hazard Ratio: 1.74 (95% CI 1.17–2.59)
Abstract
AIMS: To evaluate the association of serum phosphorus with cardiac structure/function and incident heart failure. METHODS AND RESULTS: We related serum phosphorus to echocardiographic left ventricular (LV) measurements cross-sectionally, and to incident heart failure prospectively in 3300 participants (mean age 44 years, 51% women) free of heart failure, myocardial infarction, and chronic kidney disease (estimated glomerular filtration rate eGFR90 mL/min/1.73 m(2), no proteinuria and serum phosphorus <4.5 mg/dL, the association of serum phosphorus with heart failure remained robust. CONCLUSION: In our community-based sample, higher serum phosphorus was associated with greater LV mass cross-sectionally, and with an increased risk of heart failure prospectively.