Key result
Withdrawal of ACE inhibitor therapy in hypertensive patients led to a rapid blood pressure rise to 144/94 mm Hg, which remained significantly lower than baseline (P=0.003 for SBP, P=0.002 for DBP).
Why the study?
Does trandolapril compared to perindopril reduce blood pressure rise after treatment withdrawal in hypertensive patients?
RCT (n=119)
Double-blind
Does trandolapril compared to perindopril reduce blood pressure rise after treatment withdrawal in hypertensive patients?
p-value: p=0.01
ACE inhibitor withdrawal leads to a rapid rise in BP followed by a plateau lower than baseline, with trandolapril showing better sustained BP control than perindopril.
No takes yet. Share an insight, caveat, or question.
Abrupt ACEI withdrawal warrants close BP monitoring; extends evidence favoring longer-acting agents for sustained control post-discontinuation.
L Vaur (1998) conducted an RCT in Hypertension (n=119). Trandolapril or Perindopril vs. Baseline/Placebo withdrawal was evaluated on Blood pressure rise after drug discontinuation (p=0.01). Withdrawal of ACE inhibitor therapy in hypertensive patients led to a rapid blood pressure rise to 144/94 mm Hg, which remained significantly lower than baseline (P=0.003 for SBP, P=0.002 for DBP).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: