Key result
Chronic renal failure patients on hemodialysis had significantly higher left ventricular end diastolic volume, end systolic volume, and mass index compared to matched controls.
Why the study?
How does chronic renal failure and its management (conservative vs hemodialysis) affect left ventricular morphology and function?
Observational (n=109)
How does chronic renal failure and its management (conservative vs hemodialysis) affect left ventricular morphology and function?
Hemodialysis patients with chronic renal failure exhibit significant alterations in left ventricular morphology, particularly increased LV mass index which is strongly associated with hypertension, despite preserved systolic function.
Hypertension control merits emphasis in hemodialysis; leaves open whether dialysis independently drives LV remodeling.
M-mode, two-dimensional, and Doppler echocardiography were performed in 38 chronic renal failure (CRD) patients on conservative management, 35 patients on hemodialysis, and 36 matched controls. The controls were matched for age, sex, and comorbidities. The incidence of hypertension, left ventricular (LV) end diastolic volume, LV end systolic volume, and LV mass index were significantly higher in patients on hemodialysis compared to the controls. The LV parameters in the predialysis patients were not significantly different from the controls, except the LV end systolic internal dimensions were significantly higher in the CRF patients. Multiple regression analysis underscored the strong association between increase in LV mass index (LVMI) and hypertension. The diabetic patients with renal failure had large LV internal diameter and end diastolic volume compared to non-diabetics. Systolic function was well preserved even in hypertensive and diabetic patients with uremia. The incidence of diastolic dysfunction and asymmetrical septal hypertrophy were not significantly different in the three groups of patients.
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Raj et al. (1997) conducted an observational in Chronic renal failure (n=109). Chronic renal failure (hemodialysis or conservative management) vs. Matched controls was evaluated on Left ventricular morphology and function (LV end diastolic volume, LV end systolic volume, LV mass index). Chronic renal failure patients on hemodialysis had significantly higher left ventricular end diastolic volume, end systolic volume, and mass index compared to matched controls.
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