Key result
This review summarizes the regulation of tropomyosin expression in striated muscles, focusing on translational control in vertebrate hearts using mouse and Mexican axolotl animal models.
Answers are grounded in this paper and cite their sources.
This review highlights the complex mechanisms of translational control governing tropomyosin expression in vertebrate hearts, providing insights into striated muscle regulation.
The tropomyosin (TM) gene family produces a set of related TM proteins with important functions in striated and smooth muscle, and nonmuscle cells. In vertebrate striated muscle, the thin filament consists largely of actin, TM, the troponin (Tn) complex (Tn-I, Tn-C and Tn-T), and tropomodulin (Tmod) and is responsible for mediating Ca(2+) control of muscle contraction and relaxation. There are four known genes (designated as TPM1, TPM2, TPM3, and TPM4) for TM in vertebrates. The four TM genes generate a multitude of tissue- and developmental-specific isoforms through the use of different promoters, alternative mRNA splicing, different 3'-end mRNA processing and tissue-specific translational control. In this review, we have focused mainly on the regulation of TM expression in striated muscles, primarily in vertebrate hearts with special emphasis on translational control using mouse and Mexican axolotl animal models.
No takes yet. Share an insight, caveat, or question.
Dube et al. (2014) conducted a review in Regulation of tropomyosin expression in striated muscles. This review summarizes the regulation of tropomyosin expression in striated muscles, focusing on translational control in vertebrate hearts using mouse and Mexican axolotl animal models.
Synapse has enriched 10 related papers. Consider them for comparative context: