Key result
Four novel alternatively spliced isoforms of the TPM2 gene (TPM2δ, TPM2ε, TPM2ζ, and TPM2η) were identified in human adult and fetal cardiac tissue.
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Analysis of tropomyosin 2 gene isoforms in cardiac tissue reveals differences between adult and fetal hearts, indicating potential developmental impacts.
Human adult and fetal cardiac total RNA was obtained from Zyagen (San Diego, CA) and similar protein samples were obtained from Imgenex (San Diego, CA). The samples represent in each case material from one adult heart and 5 fetal hearts.
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Dube et al. (2014) studied Normal cardiac tissue (n=6). RNA and protein expression analysis was evaluated on Detection of novel TPM2 RNA and protein isoforms. Four novel alternatively spliced isoforms of the TPM2 gene (TPM2δ, TPM2ε, TPM2ζ, and TPM2η) were identified in human adult and fetal cardiac tissue.
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