Key result
Norepinephrine provides delayed cardioprotection against myocardial stunning but increases the rate of postischemic ventricular arrhythmias.
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Offsets stunning protection with arrhythmia risk; leaves open safe translation of alpha1-mediated preconditioning.
Norepinephrine confers delayed preconditioning against myocardial stunning via an alpha(1)-adrenoceptor mediated pathway. Norepinephrine-mediated preconditioning involves a beneficial effect towards stunning, but at the expense of a higher rate of postischemic ventricular arrhythmia.
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Ralph Marktanner (2003) studied this question. Norepinephrine provides delayed cardioprotection against myocardial stunning but increases the rate of postischemic ventricular arrhythmias.
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