Key result
Metabolically healthy obesity was significantly associated with a 35% reduced risk of incident atrial fibrillation compared with metabolically unhealthy obesity (HR 0.65).
Why the study?
The modification of physical activity on metabolic status in relation to atrial fibrillation risk in obesity remains unknown.
Does metabolically healthy obesity and physical activity reduce the risk of atrial fibrillation in obese populations compared to metabolically unhealthy obesity?
Population
119,424 obese participants from UK Biobank
Comparison
MHO vs MUO and levels of physical activity
Design
Cohort study using Cox proportional hazards models
Authors
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Metabolically healthy obesity was associated with lower AF risk than unhealthy obesity; leaves open whether modifying metabolic status reduces incidence.
Cohort (n=119,424)
Yes
Does metabolically healthy obesity and physical activity reduce the risk of atrial fibrillation in obese populations compared to metabolically unhealthy obesity?
Hazard Ratio: 0.65 (95% CI 0.57–0.73)
p-value: p=<0.01
Metabolically healthy obesity is associated with a lower risk of atrial fibrillation than metabolically unhealthy obesity, and moderate-to-vigorous physical activity further reduces this risk in metabolically unhealthy individuals.
Wang et al. (2022) conducted a cohort in Obesity and Atrial Fibrillation (n=119,424). Metabolically healthy obesity (MHO) vs. Metabolically unhealthy obesity (MUO) was evaluated on Incident atrial fibrillation (HR 0.65, 95% CI 0.57-0.73, p=<0.01). Metabolically healthy obesity was significantly associated with a 35% reduced risk of incident atrial fibrillation compared with metabolically unhealthy obesity (HR 0.65).