Key result
Women with PCOS had significantly higher serum A-FABP levels than healthy controls (p<0.05), which correlated with waist-to-hip ratio (r=0.26, p=0.04) and adipose tissue percentage (r=0.33, p=0.01).
Why the study?
The risk of abdominal obesity and autoimmune thyroid disease is increased in women with PCOS, but the relationship of serum A-FABP with obesity parameters and thyroid hormone homeostasis was unclear.
Case-Control (n=133)
In non-obese women with PCOS, A-FABP levels correlate with markers of abdominal obesity independently of thyroid hormone homeostasis.
Answers are grounded in this paper and cite their sources.
A-FABP associates with abdominal obesity in PCOS independent of thyroid status; hypothesis-generating, prospective studies required before clinical consideration.
Adipocyte fatty acid-binding protein (A-FABP) is mainly expressed in adipocytes. The risk of abdominal obesity and autoimmune thyroid disease is increased in women with polycystic ovary syndrome (PCOS). The objective of this study was to explore the relationship of serum concentration of A-FABP with parameters of obesity, e.g., waist to hip ratio (WHR) and the amount of adipose tissue assessed by bioelectrical impedance analysis (BIA), and thyroid hormone homeostasis in women with PCOS. We examined 66 women with PCOS and 67 healthy women. Serum concentrations of A-FABP and thyroid hormones were measured; the FT3/FT4 ratio, thyroid-stimulating hormone index (TSHI), thyrotrope thyroxine resistance index (TT4RI) and thyroid feedback quantile-based index (TFQI) were calculated. In the PCOS group, serum concentrations of A-FABP, FT3 and the FT3/FT4 ratio were significantly higher in comparison to the control group (all p < 0.05). A correlation of A-FABP with WHR (r = 0.26, p = 0.04) and the percentage of adipose tissue (r = 0.33, p = 0.01) has been found only in women with PCOS. We observed no correlation between serum levels of A-FABP and TSHI, TT4RI or TFQI in women with PCOS (all p > 0.05). Our results indicate that A-FABP is an adipokine that may be connected with abdominal obesity independently of thyroid hormone homeostasis in PCOS patients.
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Polak et al. (2023) conducted a case-control in Polycystic Ovary Syndrome (n=133). Polycystic Ovary Syndrome vs. Healthy women was evaluated on Serum concentrations of A-FABP, FT3, and FT3/FT4 ratio (p=< 0.05). Women with PCOS had significantly higher serum A-FABP levels than healthy controls (p<0.05), which correlated with waist-to-hip ratio (r=0.26, p=0.04) and adipose tissue percentage (r=0.33, p=0.01).
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