Key result
Pharmacological lowering of blood pressure over 1 year improved neuropsychological performance, with greater BP reduction linked to altered regional cerebral blood flow responsivity.
Why the study?
Does pharmacological blood pressure lowering alter regional cerebral blood flow and neuropsychological performance in hypertensive patients?
Cohort (n=43)
Does pharmacological blood pressure lowering alter regional cerebral blood flow and neuropsychological performance in hypertensive patients?
Successful pharmacological lowering of blood pressure in hypertensive patients is associated with distinct changes in regional cerebral blood flow during cognitive tasks.
No takes yet. Share an insight, caveat, or question.
BP lowering may improve cognition in hypertension; hypothesis-generating for CBF mediation and needs RCTs before practice change.
Jennings et al. (2010) conducted a cohort in essential hypertension (n=43). Pharmacological treatment for hypertension vs. Pre-treatment baseline was evaluated on Neuropsychological performance and regional cerebral blood flow (rCBF). Pharmacological lowering of blood pressure over 1 year improved neuropsychological performance, with greater BP reduction linked to altered regional cerebral blood flow responsivity.
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