Key result
Oxidative stress may not be as important in mediating hypertension in females as in males, suggesting future clinical trials of antioxidants should evaluate effects separately by sex.
Why the study?
Do antioxidants reduce blood pressure differently in men and women with hypertension?
Do antioxidants reduce blood pressure differently in men and women with hypertension?
This review highlights potential sex differences in the role of oxidative stress in hypertension, suggesting that future clinical trials of antioxidants should be powered to evaluate effects separately in men and women.
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May warrant sex-specific antioxidant trials in hypertension; leaves open differential oxidative mechanisms by sex and age.
Lopez‐Ruiz et al. (2008) conducted a review in Hypertension. Oxidative stress was evaluated. Oxidative stress may not be as important in mediating hypertension in females as in males, suggesting future clinical trials of antioxidants should evaluate effects separately by sex.
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