Key result
Antioxidants fail to reduce blood pressure in clinical trials despite preclinical oxidative stress evidence.
Why the study?
Whether maintenance of hypertension in females is mediated by oxidative stress remains unclear, and clinical studies targeting BP with antioxidants have yielded conflicting, mostly negative results.
Do antioxidants reduce blood pressure in hypertension?
Do antioxidants reduce blood pressure in hypertension?
While animal models suggest oxidative stress drives hypertension, clinical trials of antioxidants have largely failed to reduce blood pressure, highlighting a translational gap.
No takes yet. Share an insight, caveat, or question.
Antioxidants lack support for hypertension treatment; leaves open whether oxidative stress targeting can succeed beyond male preclinical models.
Reckelhoff et al. (2019) conducted a review in Hypertension. Antioxidants was evaluated on Blood pressure. Preclinical studies support oxidative stress in hypertension development in male animals, while clinical trials of antioxidants for blood pressure reduction have yielded mostly negative results.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: