Key result
Evidence supporting the link between hypertension and oxidative stress remains inconclusive, and studies investigating anti-oxidant supplements have failed to show consistent benefit.
Why the study?
Does anti-oxidant supplementation lower blood pressure in patients with hypertension?
Current evidence does not support the use of anti-oxidant supplements for lowering blood pressure, as data linking oxidative stress to hypertension remains inconclusive.
Anti-oxidant supplements should not be used for hypertension; leaves open oxidative stress contribution pending rigorous trials.
Oxidative stress has been suggested to be involved in the pathogenesis of hypertension. This may be via a number of possible mechanisms, including quenching of the important vasodilator nitric oxide. 2. Animal studies have generally supported the hypothesis that increased blood pressure is associated with increased oxidative stress. However, human studies have been inconsistent and may differ owing to the populations studied and the various methods used. Treatment with anti-oxidants has been suggested to lower oxidative stress and, therefore, blood pressure. However, to date, studies investigating single or combination supplements have failed to show any consistent benefit. 3. Overall, the evidence supporting the link between hypertension and oxidative stress remains inconclusive, with methodological and population differences possibly confounding results. Further studies investigating this relationship are warranted.
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Ward et al. (2006) conducted a review in Hypertension. Oxidative stress and anti-oxidant supplements was evaluated. Evidence supporting the link between hypertension and oxidative stress remains inconclusive, and studies investigating anti-oxidant supplements have failed to show consistent benefit.
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