Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 19, 2026Current Hypertension Reviews

Oxidative Stress and Antioxidants in Hypertension: A Review onMechanisms and Clinical Challenges

View Full Paper
Ask AI
Bookmark
Share

Authors

MCMostafa CheraghiFHFatemeh HatamiMDM Dehghani

Discussion

Loading...

Member takes

Overview

Review explores oxidative stress mechanisms in hypertension and examines clinical challenges of antioxidant therapies.

Key Points

  • This review investigates the role of oxidative stress in hypertension and evaluates the effectiveness of antioxidant therapies.
  • Synthesized mechanistic evidence on oxidative stress and hypertension.
  • Evaluated clinical data on antioxidant interventions in hypertensive patients.
  • Discussed preclinical and animal study findings on oxidative stress and blood pressure.
  • Preclinical studies strongly link elevated ROS to increased blood pressure and end-organ injury.
  • Clinical trials showed inconsistent results for antioxidant therapies despite mechanistic support.
  • Current evidence does not recommend routine antioxidant use as antihypertensive therapy.

Cite This Study

Cheraghi et al. (2026) studied this question.

synapsesocial.com/papers/6a34def565a5b0777af2e301https://doi.org/10.2174/0115734021430579260608102038
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oxidative Stress and Antioxidants in Hypertension–A Current Review2015 · 353 citations
  2. 2The Future Challenge of Reactive Oxygen Species (ROS) in Hypertension: From Bench to Bed Side2017 · 99 citations
  3. 3Targeting endothelial oxidative stress in hypertension2025 · 1 citations
  4. 4Reactive Oxygen Species, Vascular Oxidative Stress, and Redox Signaling in Hypertension2004 · 869 citations
  5. 5Antioxidant therapy for management of oxidative stress induced hypertension2017 · 121 citations